Natural ingredients bioavailability is a well known issue and different strategies have been developed to ameliorate the absorption. The first one, chemical derivatization, is applied to obtain compounds showing an improved bioavailability. This approach, however, generates a number of chemical analogues that need to be appropriately screened. An alternative strategy that is also being pursued is the combination of the active molecules with other compounds as adjuvants promoting the active molecule’s absorption.
A third approach involves extensive formulation research of structures capable of both stabilizing natural molecules and promoting their intestinal absorption. The formulative reasearch comprises the formation of liposomes, micelles, nanoparticles, nanoemulsions, microsphere or other complexes.
With the Phytosome® approach the pharmacokinetic profile is guaranteed without resorting to pharmacological adjuvants or structural modification of the ingredients, but by formulating them with a dietary ingredient (lecithin from non GMO soy).
Based on this technology, a line of products has been developed and commercialized by Indena (table 1).
|18ß-glycyrrhetinic acid Phytosome®||18ß-glycyrrhetinic acid from licorice rhizome||Soothing|
|Boswellia Phytosome®||Boswellic acids from Boswellia serrata's resins||Healthy inflammatory response, Soothing, Lenitive|
|Centella Phytosome®||Triterpenes from Centella asiatica leaf||Collagen restructurant, Antiwrinkles agent|
|Crataegus Phytosome®||Vitexin-2″-O-rhamnoside from Hawthorn flower||Antioxidant|
|Escin ß-sitosterol Phytosome®||Escin ß-sitosterol from horse chestnut fruit||Capillarotropic|
|Ginkgoselect® Phytosome®||Escin ß-sitosterol from horse chestnut fruit||Capillarotropic|
|Ginselect® Phytosome®||Ginsenosides from Panax ginseng rhizome||Adaptogen, Tonic, Skin elasticity improver|
|Ginkgo biloba Terpenes Phytosome®||Ginkgolides and bilobalide from Ginkgo biloba leaf||Soothing|
|Ginkgo biloba Dimeric Flavonoids Phytosome®||Dimeric flavonoids from Ginkgo biloba leaf||Lipolytic, vasokinetic|
|Greenselect® Phytosome®||Polyphenols from green tea leaf||Wheight loss agent, Antioxidant|
|Leucoselect® Phytosome®||Polyphenols from grape seed||Antioxidant, capillarotropic|
|Meriva®||Curcuminoids from turmeric rhizome||Joint health, Healthy inflammatory response|
|PA2 Phytosome®||Proanthocyanidin A2 from horse chestnut bark||Anti-wrinkles, UV protectant|
|Resveratrol Phytosome®||Resveratrol from Polygonum cuspidatum's rizhome||Antioxidant|
|Sericoside Phytosome®||Sericoside from Terminalia sericea bark root||Anti-wrinkles|
|Siliphos®||Silybin from milk thistle seed||Healthy Liver, Retinoic acid-like compound|
|Silymarin Phytosome®||Silymarin from milk thistle seed||Healthy liver, Antioxidant, UV protectant|
|Virtiva®||Ginkgoflavonglucosides, ginkgolides, bilobalide from Ginkgo biloba leaf||Vasokinetic|
|Visnadex®||Visnadin from Amni visnaga umbel||Vasokinetic|