Phytosome® overview

Natural ingredients bioavailability is a well known issue and different strategies have been developed to ameliorate the absorption. The first one, chemical derivatization, is applied to obtain compounds showing an improved bioavailability. This approach, however, generates a number of chemical analogues that need to be appropriately screened. An alternative strategy that is also being pursued is the combination of the active molecules with other compounds as adjuvants promoting the active molecule’s absorption.
A third approach involves extensive formulation research of structures capable of both stabilizing natural molecules and promoting their intestinal absorption. The formulative reasearch comprises the formation of liposomes, micelles, nanoparticles, nanoemulsions, microsphere or other complexes.

With the Phytosome® approach the pharmacokinetic profile is guaranteed without resorting to pharmacological adjuvants or structural modification of the ingredients, but by formulating them with a dietary ingredient (lecithin from non GMO soy).

Based on this technology, a line of products has been developed and commercialized by Indena (table 1).

Trade name Phytochemical Indication
18ß-glycyrrhetinic acid Phytosome® 18ß-glycyrrhetinic acid from licorice rhizome Soothing
Boswellia Phytosome® Boswellic acids from Boswellia serrata's resins Healthy inflammatory response, Soothing, Lenitive
Centella Phytosome® Triterpenes from Centella asiatica leaf Collagen restructurant, Antiwrinkles agent
Crataegus Phytosome® Vitexin-2″-O-rhamnoside from Hawthorn flower Antioxidant
Escin ß-sitosterol Phytosome® Escin ß-sitosterol from horse chestnut fruit Capillarotropic
Ginkgoselect® Phytosome® Escin ß-sitosterol from horse chestnut fruit Capillarotropic
Ginselect® Phytosome® Ginsenosides from Panax ginseng rhizome Adaptogen, Tonic, Skin elasticity improver
Ginkgo biloba Terpenes Phytosome® Ginkgolides and bilobalide from Ginkgo biloba leaf Soothing
Ginkgo biloba Dimeric Flavonoids Phytosome® Dimeric flavonoids from Ginkgo biloba leaf Lipolytic, vasokinetic
Greenselect® Phytosome® Polyphenols from green tea leaf Wheight loss agent, Antioxidant
Leucoselect® Phytosome® Polyphenols from grape seed Antioxidant, capillarotropic
Meriva® Curcuminoids from turmeric rhizome Joint health, Healthy inflammatory response
PA2 Phytosome® Proanthocyanidin A2 from horse chestnut bark Anti-wrinkles, UV protectant
Resveratrol Phytosome® Resveratrol from Polygonum cuspidatum's rizhome Antioxidant
Sericoside Phytosome® Sericoside from Terminalia sericea bark root Anti-wrinkles
Siliphos® Silybin from milk thistle seed Healthy Liver, Retinoic acid-like compound
Silymarin Phytosome® Silymarin from milk thistle seed Healthy liver, Antioxidant, UV protectant
Virtiva® Ginkgoflavonglucosides, ginkgolides, bilobalide from Ginkgo biloba leaf Vasokinetic
Visnadex® Visnadin from Amni visnaga umbel Vasokinetic
Table 1. Commercially available Phytosome®s and their trademarks